MSX1

Across TCGA patient cohorts, MSX1 protein abundance is significantly associated with the RNA expression of many other genes, with 741 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSX1-associated genes across cancer lineages are IGSF21, HIF1A, and DHRS2. Each is linked with MSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSX1-to-partner and partner-to-MSX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSX1 versus IGSF21 in OV, with a Pearson correlation of -0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX1→partner) and Y-score (partner→MSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGSF21 →	-0.855	-0.830	.001	.002	3	2
UCEC	HIF1A →	+0.464	+0.386	<.001	<.001	3	1
UCEC	DHRS2 →	-0.618	-0.437	.003	.007	3	1
UCEC	DOK5 →	-1.258	-0.501	<.001	<.001	3	1
UCEC	BMP7 →	-1.015	-0.438	<.001	<.001	3	1
UCEC	CDC25B →	-0.448	-0.349	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 741 associations by consensus.

MSX1 vs IGSF21 — OV

Explore this scatter interactively →