MSX1

Across TCGA patient cohorts, MSX1 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSX1-associated genes across cancer lineages are OR2T3, LIMS4, and MIR4479. Each is linked with MSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSX1-to-partner and partner-to-MSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T3 grouped by MSX1-low versus MSX1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX1→partner) and Y-score (partner→MSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR2T3 →	+0.072	+4.540	<.001	.009	3	2
BRCA	LIMS4 →	+0.014	+7.473	<.001	.007	3	1
BRCA	MIR4479 →	+0.565	+4.526	.002	.005	3	1
BRCA	ECM1P1 →	+0.063	+5.026	<.001	.002	3	1
COAD	TMCO5B →	+0.088	+5.080	<.001	.008	3	1
COAD	LINC01995 →	+0.336	+6.003	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

OR2T3 by MSX1 expression — BRCA

Explore this box plot interactively →