MSX1

Across TCGA cell cohorts, MSX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,954 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSX1-associated GO terms across cancer lineages are Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, Regulation of heart contraction, and Positive regulation of odontogenesis. Each is linked with MSX1 in more than 10 cancer types. Because this analysis shows association rather than direction, both MSX1-to-partner and partner-to-MSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator grouped by MSX1-low versus MSX1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSX1→partner) and Y-score (partner→MSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	-0.082	-1.250	.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of heart contraction →	-0.119	-0.889	.001	.003	3	9
OVARY	Positive regulation of odontogenesis →	+1.321	+1.738	<.001	.006	3	9
OESOPHAGUS	Enzyme-directed rRNA pseudouridine synthesis →	+0.080	+1.047	.008	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of sodium ion transport →	-0.194	-0.864	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Heart valve formation →	-0.133	-0.690	.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,954 associations by consensus.

Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator by MSX1 expression — LARGE_INTESTINE

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