MSTO1

Across TCGA pan-cancer cohorts, MSTO1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MSTO1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MSTO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MSTO1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where MSTO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MSTO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.262	<.001	12	view →
KIRC	Female	IV	+0.786	<.001	12	view →
COAD	Female	III,IV	+1.094	<.001	11	view →
LIHC	Male	All	+1.862	<.001	9	view →
LUAD	Female	III,IV	+1.395	<.001	9	view →
LUSC	Female	II,III,IV	+1.094	<.001	9	view →
BLCA	Female	III,IV	+0.980	<.001	9	view →
STAD	All	II,III,IV	+0.958	<.001	9	view →
KICH	Female	II,III,IV	−1.187	<.001	8	view →
UCEC	All	All	+0.629	<.001	6	view →
CHOL	Male	All	+2.438	<.001	5	view →
ESCA	All	All	+0.712	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MSTO1–HNSC

Open the HNSC breakdown →