Across TCGA patient cohorts, MST1L mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MST1L-associated genes across cancer lineages are RNU6-1029P, UBTFL7, and LAMTOR1. Each is linked with MST1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MST1L-to-partner and partner-to-MST1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MST1L→partner) and Y-score (partner→MST1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1029P →	+0.413	+4.532	.001	.005	3	2
UCEC	UBTFL7 →	+0.110	+2.591	.002	.002	3	2
UCEC	LAMTOR1 →	+0.404	+3.202	.009	.009	3	1
UCEC	SAR1B →	+0.575	+3.584	.001	.003	3	1
UCEC	NTAN1 →	+0.631	+3.346	<.001	.005	3	1
UCEC	GRIN2C →	+0.508	+3.531	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

Exploration

MST1L survival (RNA) · tumor vs normal (RNA) · all MST1L data types