Across TCGA patient cohorts, MST1L mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MST1L-associated genes across cancer lineages are MEK1, STAT3_pY705, and Rad50. Each is linked with MST1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MST1L-to-partner and partner-to-MST1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MST1L→partner) and Y-score (partner→MST1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.502	+3.169	.006	.019	3	1
UCEC	STAT3_pY705 →	-0.390	-3.159	.003	.019	3	1
UCEC	Rad50 →	-0.241	-3.459	.048	.005	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

MST1L survival (RNA) · tumor vs normal (RNA) · all MST1L data types