MST1

Across TCGA pan-cancer cohorts, MST1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MST1 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MST1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MST1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where MST1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.676	1.000	.002	44	view →
LUAD	OS	Quartile	III,IV	0.228	0.719	.005	11	view →
HNSC	DFS	Tertile	All	1.000	0.623	.040	6	view →
GBM	OS	Tertile	All	0.894	0.632	.010	5	view →
CCRCC	DFS	Median	II,III,IV	0.260	0.762	.013	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MST1–LSCC (DFS)

Open the LSCC breakdown →