MST1

Across TCGA cell cohorts, MST1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MST1-associated genes across cancer lineages are GML, BTBD16, and MAEL. Each is linked with MST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MST1-to-partner and partner-to-MST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by MST1-low versus MST1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MST1→partner) and Y-score (partner→MST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.084	+3.889	<.001	<.001	3	1
BLOOD_Leukemia	BTBD16 →	+0.098	+3.281	<.001	.003	3	1
BLOOD_Leukemia	MAEL →	+0.285	+3.459	.009	.006	3	1
BLOOD_Leukemia	LRIT1 →	+0.026	+3.269	<.001	.007	3	1
BLOOD_Leukemia	TRAT1 →	+2.477	+3.754	.001	.002	3	1
BLOOD_Leukemia	EGFLAM →	+0.198	+3.710	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GML by MST1 expression — BLOOD_Leukemia

Explore this box plot interactively →