MSS51

Across TCGA pan-cancer cohorts, MSS51 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MSS51 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MSS51 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MSS51 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

KIRC, ESCA, and CHOL are the cancer types where MSS51 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
ESCA	OS	Median	All	0.136	0.700	<.001	24	view →
CHOL	OS	Median	All	0.089	0.727	.001	9	view →
BRCA	OS	Median	All	0.927	0.924	.046	2	view →
UCEC	DFS	Median	All	0.943	0.624	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MSS51–KIRC (OS)

Open the KIRC breakdown →