MSS51

Across TCGA cell cohorts, MSS51 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSS51-associated genes across cancer lineages are GABRA6, METTL11B, and MYO3A. Each is linked with MSS51 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSS51-to-partner and partner-to-MSS51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRA6 grouped by MSS51-low versus MSS51-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSS51→partner) and Y-score (partner→MSS51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GABRA6 →	+0.372	+3.345	<.001	.007	3	1
LARGE_INTESTINE	METTL11B →	+0.168	+3.453	.009	.009	3	1
LARGE_INTESTINE	MYO3A →	+0.952	+3.491	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GABRA6 by MSS51 expression — LARGE_INTESTINE

Explore this box plot interactively →