MSRB3

Across TCGA pan-cancer cohorts, MSRB3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MSRB3 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MSRB3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MSRB3 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and LUAD are the cancer types where MSRB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.441	0.863	.001	29	view →
CCRCC	OS	Tertile	IV	0.198	0.830	.024	21	view →
LUAD	DFS	Tertile	II,III,IV	0.785	0.998	.003	15	view →
HNSC	DFS	Median	IV	0.586	0.790	.027	1	view →
GBM	OS	Median	All	0.760	0.944	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MSRB3–LSCC (DFS)

Open the LSCC breakdown →