MSRB3

Across TCGA patient cohorts, MSRB3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSRB3-associated genes across cancer lineages are PKC-b-II_pS660, PCNA, and EGFR. Each is linked with MSRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSRB3-to-partner and partner-to-MSRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by MSRB3-low versus MSRB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRB3→partner) and Y-score (partner→MSRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.388	-3.000	.015	.036	3	1
UCEC	PCNA →	+0.400	+3.000	.001	.036	2	1
UCEC	EGFR →	-0.244	-3.000	.008	.037	1	1
UCEC	eIF4E →	+0.304	+3.000	.012	.037	1	1
UCEC	MEK1 →	+0.530	+3.000	.012	.037	1	1
UCEC	mTOR_pS2448 →	-0.251	-3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PKC-b-II_pS660 by MSRB3 expression — UCEC

Explore this box plot interactively →