MSRB3

Across TCGA cell cohorts, MSRB3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSRB3-associated genes across cancer lineages are AVP, REG3G, and FAM205A. Each is linked with MSRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSRB3-to-partner and partner-to-MSRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by MSRB3-low versus MSRB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRB3→partner) and Y-score (partner→MSRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	2
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+3.614	<.001	.006	3	1
LARGE_INTESTINE	SHISA8 →	+0.337	+3.626	<.001	.006	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AVP by MSRB3 expression — LARGE_INTESTINE

Explore this box plot interactively →