MSRB2

Across TCGA patient cohorts, MSRB2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSRB2-associated genes across cancer lineages are INPP4B, p38-MAPK, and Rab25. Each is linked with MSRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSRB2-to-partner and partner-to-MSRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by MSRB2-low versus MSRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRB2→partner) and Y-score (partner→MSRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.450	-3.156	.011	.020	3	1
UCEC	p38-MAPK →	-0.206	-3.169	.022	.020	3	1
UCEC	Rab25 →	-0.495	-3.169	.006	.020	3	1
UCEC	YB-1 →	+0.196	+3.196	.024	.010	3	1
UCEC	Paxillin →	+0.348	+3.009	.014	.019	2	1
UCEC	Smad3 →	+0.179	+3.169	.030	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

INPP4B by MSRB2 expression — UCEC

Explore this box plot interactively →