MSRB2

Across TCGA cell cohorts, MSRB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,032 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MSRB2-associated GO terms across cancer lineages are Protein repair, Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Negative regulation of macrophage chemotaxis. Each is linked with MSRB2 in more than 12 cancer types. Because this analysis shows association rather than direction, both MSRB2-to-partner and partner-to-MSRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein repair grouped by MSRB2-low versus MSRB2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSRB2→partner) and Y-score (partner→MSRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Protein repair →	+0.159	+1.083	<.001	<.001	3	13
SKIN	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.101	-0.994	<.001	<.001	3	10
OESOPHAGUS	Negative regulation of macrophage chemotaxis →	-0.186	-1.154	.001	.001	3	9
OESOPHAGUS	snRNA transcription by RNA polymerase III →	-0.089	-1.405	.003	.006	3	9
BONE	Positive regulation of nuclear cell cycle DNA replication →	-0.180	-1.349	.001	.001	3	8
BONE	rRNA metabolic process →	-0.109	-1.141	.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,032 associations by consensus.

Protein repair by MSRB2 expression — SOFT_TISSUE

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