Across TCGA pan-cancer cohorts, MSRB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MSRB1 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MSRB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MSRB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where MSRB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	1.000	0.819	.019	12	view →
GBM	DFS	Tertile	All	0.259	0.561	.014	10	view →
PDAC	OS	Median	II,III,IV	0.515	0.968	.009	7	view →
LSCC	DFS	Median	III,IV	1.000	0.851	.048	2	view →
HNSC	DFS	Quartile	All	0.874	0.646	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MSRB1 tumor-vs-normal RNA expression · all MSRB1 data types