MSMO1

Across TCGA pan-cancer cohorts, MSMO1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MSMO1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MSMO1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MSMO1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where MSMO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.756	0.420	<.001	88	view →
CCRCC	OS	Tertile	All	0.605	0.964	<.001	50	view →
LUAD	DFS	Median	All	0.353	0.902	<.001	29	view →
PDAC	DFS	Median	II,III,IV	0.639	0.828	.030	13	view →
LSCC	DFS	Median	II,III,IV	0.667	0.860	.013	12	view →
OV	DFS	Tertile	All	0.563	0.942	.011	4	view →
UCEC	DFS	Median	II,III,IV	0.885	0.530	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MSMO1–HNSC (DFS)

Open the HNSC breakdown →