MSMB

Across TCGA patient cohorts, MSMB protein abundance is significantly associated with the RNA expression of many other genes, with 1,229 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MSMB-associated genes across cancer lineages are CACNG6, RAB1A, and PIGF. Each is linked with MSMB in more than 1 cancer types. Because this analysis shows association rather than direction, both MSMB-to-partner and partner-to-MSMB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSMB versus CACNG6 in LUAD, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSMB→partner) and Y-score (partner→MSMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CACNG6 →	+0.776	+2.286	.005	.003	3	2
LSCC	RAB1A →	+0.353	+1.179	.003	.003	3	2
LUAD	PIGF →	+0.476	+2.122	.001	.001	3	2
LUAD	LDLRAD1 →	+1.401	+2.586	.004	.005	3	2
LUAD	SMIM26 →	+0.778	+3.079	.001	.001	3	2
HNSC	MEP1A →	-0.442	-1.307	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

MSMB vs CACNG6 — LUAD

Explore this scatter interactively →