MSLNL

Across TCGA patient cohorts, MSLNL mutation is significantly associated with the RNA expression of many other genes, with 1,799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSLNL-associated genes across cancer lineages are RNA5SP110, MFAP1, and FBXO25. Each is linked with MSLNL in more than 2 cancer types. Because this analysis shows association rather than direction, both MSLNL-to-partner and partner-to-MSLNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP110 grouped by MSLNL-low versus MSLNL-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLNL→partner) and Y-score (partner→MSLNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP110 →	+0.216	+4.303	<.001	.009	3	3
UCEC	MFAP1 →	+0.570	+2.673	<.001	<.001	3	3
UCEC	FBXO25 →	+0.374	+2.361	.003	.003	3	3
READ	ASH2LP1 →	+0.056	+5.925	<.001	.002	3	2
READ	RPL12P5 →	+0.118	+5.219	.001	.006	3	2
UCEC	COX15 →	+0.474	+2.423	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,799 associations by consensus.

RNA5SP110 by MSLNL expression — LUAD

Explore this box plot interactively →