MSLNL

Across TCGA patient cohorts, MSLNL mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSLNL-associated genes across cancer lineages are ERK2, Ku80, and TIGAR. Each is linked with MSLNL in more than 1 cancer types. Because this analysis shows association rather than direction, both MSLNL-to-partner and partner-to-MSLNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MSLNL-low versus MSLNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLNL→partner) and Y-score (partner→MSLNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.208	+3.459	.008	.005	3	2
UCEC	Ku80 →	+0.219	+1.884	.025	.030	3	2
UCEC	TIGAR →	+0.135	+3.026	.032	<.001	3	2
UCEC	ATM →	-0.402	-2.321	.031	.006	3	2
COAD	PKC-b-II_pS660 →	-0.497	-3.161	.004	.019	3	1
COAD	Rad50 →	-0.421	-3.000	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by MSLNL expression — UCEC

Explore this box plot interactively →