MSLN

Across TCGA patient cohorts, MSLN RNA expression is significantly associated with the protein abundance of many other proteins, with 16,337 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MSLN-associated proteins across cancer lineages are CAPG, MISP, and MSLN_S200. Each is linked with MSLN in more than 5 cancer types. Because this analysis shows association rather than direction, both MSLN-to-partner and partner-to-MSLN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSLN versus CAPG in GBM, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLN→partner) and Y-score (partner→MSLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CAPG →	+0.364	+0.534	<.001	<.001	3	6
UCEC	MISP →	+0.766	+1.933	<.001	.001	3	5
CCRCC	MSLN_S200 →	+2.350	+4.965	<.001	<.001	3	5
GBM	MVP →	+0.627	+0.892	<.001	<.001	3	5
UCEC	ZNF185 →	+0.562	+2.219	<.001	<.001	3	5
UCEC	EPB41L1 →	+0.572	+2.132	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,337 associations by consensus.

MSLN vs CAPG — GBM

Explore this scatter interactively →