MSLN

Across TCGA patient cohorts, MSLN protein abundance is significantly associated with the RNA expression of many other genes, with 15,846 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MSLN-associated genes across cancer lineages are MSLNL, TRIM29, and UPK3B. Each is linked with MSLN in more than 7 cancer types. Because this analysis shows association rather than direction, both MSLN-to-partner and partner-to-MSLN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSLN versus MSLNL in LUAD, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLN→partner) and Y-score (partner→MSLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MSLNL →	+1.187	+1.061	<.001	<.001	3	8
BRCA	TRIM29 →	+2.170	+1.403	.001	<.001	3	5
OV	UPK3B →	+2.207	+0.770	<.001	.001	3	5
CCRCC	LINC01836 →	+0.934	+0.861	.002	.004	3	5
BRCA	VGLL1 →	+3.371	+1.530	<.001	<.001	3	4
UCEC	SEMA3B →	+0.912	+0.670	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,846 associations by consensus.

MSLN vs MSLNL — LUAD

Explore this scatter interactively →