MSLN

Across TCGA patient cohorts, MSLN mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSLN-associated genes across cancer lineages are Chk1, 14-3-3_beta, and N-Ras. Each is linked with MSLN in more than 1 cancer types. Because this analysis shows association rather than direction, both MSLN-to-partner and partner-to-MSLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by MSLN-low versus MSLN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLN→partner) and Y-score (partner→MSLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.257	+2.820	.019	.035	3	2
UCEC	14-3-3_beta →	-0.149	-2.571	.001	.011	3	1
UCEC	N-Ras →	-0.182	-2.302	.001	.034	3	1
UCEC	p38-MAPK →	+0.186	+2.189	.015	.034	3	1
UCEC	AMPK_pT172 →	+0.448	+3.459	.019	.005	3	1
UCEC	Rab25 →	-0.552	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Chk1 by MSLN expression — SKCM

Explore this box plot interactively →