MSLN

Across TCGA cell cohorts, MSLN RNA expression is significantly associated with the go_rna of many other GO terms, with 2,798 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible MSLN-associated GO terms across cancer lineages are Positive regulation of bicellular tight junction assembly, Response to progesterone, and Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with MSLN in more than 7 cancer types. Because this analysis shows association rather than direction, both MSLN-to-partner and partner-to-MSLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of bicellular tight junction assembly grouped by MSLN-low versus MSLN-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLN→partner) and Y-score (partner→MSLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of bicellular tight junction assembly →	+0.212	+2.302	.002	.003	3	8
STOMACH	Response to progesterone →	+0.203	+4.295	<.001	<.001	3	8
LARGE_INTESTINE	Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.110	+2.679	<.001	.002	3	7
OESOPHAGUS	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.179	+3.627	<.001	<.001	3	7
OVARY	Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	+0.955	+2.581	<.001	<.001	3	7
OVARY	Response to mycotoxin →	+0.603	+3.361	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,798 associations by consensus.

Positive regulation of bicellular tight junction assembly by MSLN expression — BREAST

Explore this box plot interactively →