MSLN

Across TCGA cell cohorts, MSLN mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MSLN-associated genes across cancer lineages are PATE1, PPP1R2C, and GH2. Each is linked with MSLN in more than 1 cancer types. Because this analysis shows association rather than direction, both MSLN-to-partner and partner-to-MSLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATE1 grouped by MSLN-low versus MSLN-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSLN→partner) and Y-score (partner→MSLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PATE1 →	+0.033	+2.974	<.001	.006	3	2
BLOOD_Leukemia	PPP1R2C →	+0.174	+4.539	<.001	<.001	3	2
BLOOD_Leukemia	GH2 →	+0.014	+3.969	<.001	.009	3	2
BLOOD_Leukemia	DMRTB1 →	+0.043	+4.475	<.001	<.001	3	2
BLOOD_Leukemia	OR2D3 →	+0.070	+3.289	<.001	.009	3	2
SOFT_TISSUE	WFDC11 →	+0.160	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PATE1 by MSLN expression — OVARY

Explore this box plot interactively →