MSL2

Across TCGA patient cohorts, MSL2 mutation is significantly associated with the RNA expression of many other genes, with 3,258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSL2-associated genes across cancer lineages are PSAT1P4, TOMM22, and WFDC2. Each is linked with MSL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSL2-to-partner and partner-to-MSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by MSL2-low versus MSL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSL2→partner) and Y-score (partner→MSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSAT1P4 →	+0.097	+4.381	.001	.006	3	3
UCEC	TOMM22 →	+0.369	+1.709	<.001	<.001	3	2
UCEC	WFDC2 →	-1.030	-2.125	.003	<.001	3	2
UCEC	CORO2B →	-0.545	-3.989	<.001	<.001	3	2
UCEC	PLGRKT →	+0.434	+1.698	.003	<.001	3	2
UCEC	BCCIP →	+0.296	+1.974	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,258 associations by consensus.

PSAT1P4 by MSL2 expression — SKCM

Explore this box plot interactively →