MSL2

Across TCGA cell cohorts, MSL2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MSL2-associated genes across cancer lineages are LORICRIN, C9orf92, and CNTN3. Each is linked with MSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSL2-to-partner and partner-to-MSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LORICRIN grouped by MSL2-low versus MSL2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSL2→partner) and Y-score (partner→MSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LORICRIN →	+0.032	+4.930	<.001	.008	3	1
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
BLOOD_Lymphoma	CNTN3 →	+0.088	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	SCP2D1 →	+0.037	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	GABRA6 →	+0.133	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	A3GALT2 →	+0.030	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

LORICRIN by MSL2 expression — SOFT_TISSUE

Explore this box plot interactively →