MSI2

Across TCGA patient cohorts, MSI2 protein abundance is significantly associated with the RNA expression of many other genes, with 18,689 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MSI2-associated genes across cancer lineages are C5AR1, CSF2RB, and DSE. Each is linked with MSI2 in more than 7 cancer types. Because this analysis shows association rather than direction, both MSI2-to-partner and partner-to-MSI2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSI2 versus C5AR1 in OV, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSI2→partner) and Y-score (partner→MSI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C5AR1 →	-0.905	-0.436	<.001	<.001	3	8
LSCC	CSF2RB →	-1.035	-0.707	<.001	<.001	3	7
GBM	DSE →	-0.769	-0.362	<.001	<.001	3	7
GBM	KMO →	-0.685	-0.307	<.001	.001	3	7
COAD	BCL2A1 →	-1.140	-0.381	.002	<.001	3	7
GBM	CD53 →	-0.999	-0.462	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,689 associations by consensus.

MSI2 vs C5AR1 — OV

Explore this scatter interactively →