MSI1

Across TCGA patient cohorts, MSI1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,248 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MSI1-associated genes across cancer lineages are RPS27P25, CDK2, and KLHL23. Each is linked with MSI1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MSI1-to-partner and partner-to-MSI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSI1 versus RPS27P25 in OV, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSI1→partner) and Y-score (partner→MSI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPS27P25 →	+1.165	+1.036	<.001	<.001	3	7
OV	CDK2 →	+0.628	+0.997	.001	<.001	3	6
HNSC	KLHL23 →	+1.740	+1.167	<.001	<.001	3	6
HNSC	CSRNP2 →	+0.577	+0.922	<.001	<.001	3	5
HNSC	BCL7A →	+0.765	+0.951	.005	.002	3	5
GBM	TGIF2 →	+0.853	+0.404	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,248 associations by consensus.

MSI1 vs RPS27P25 — OV

Explore this scatter interactively →