MSI1

Across TCGA patient cohorts, MSI1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSI1-associated genes across cancer lineages are PRDX1, TIGAR, and Bad_pS112. Each is linked with MSI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSI1-to-partner and partner-to-MSI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by MSI1-low versus MSI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSI1→partner) and Y-score (partner→MSI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.238	+2.999	.013	.035	3	1
UCEC	TIGAR →	+0.185	+1.901	.009	.031	3	1
UCEC	Bad_pS112 →	-0.172	-3.000	.048	.036	3	1
UCEC	Chk2_pT68 →	-0.184	-2.312	.034	.034	3	1
UCEC	ERK2 →	+0.196	+3.169	.029	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRDX1 by MSI1 expression — UCEC

Explore this box plot interactively →