MSI1

Across TCGA cell cohorts, MSI1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MSI1-associated genes across cancer lineages are KRTAP4-1, GPR26, and SCGB3A2. Each is linked with MSI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSI1-to-partner and partner-to-MSI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-1 grouped by MSI1-low versus MSI1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSI1→partner) and Y-score (partner→MSI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	2
BLOOD_Leukemia	GPR26 →	+0.077	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.144	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR10Q1 →	+0.032	+5.969	<.001	.001	3	1
BLOOD_Leukemia	LRRC55 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCM →	+0.038	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KRTAP4-1 by MSI1 expression — BLOOD_Lymphoma

Explore this box plot interactively →