MSH4

Across TCGA patient cohorts, MSH4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,088 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MSH4-associated GO terms across cancer lineages are Autophagosome organization, Positive regulation of DNA metabolic process, and Regulation of nucleotide-excision repair. Each is linked with MSH4 in more than 27 cancer types. Because this analysis shows association rather than direction, both MSH4-to-partner and partner-to-MSH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autophagosome organization grouped by MSH4-low versus MSH4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH4→partner) and Y-score (partner→MSH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Autophagosome organization →	+0.091	+0.254	<.001	<.001	3	28
ESCA	Positive regulation of DNA metabolic process →	+0.052	+0.253	<.001	<.001	3	28
ESCA	Regulation of nucleotide-excision repair →	+0.083	+0.364	<.001	<.001	3	28
STAD	Nuclear-transcribed mRNA catabolic process →	+0.099	+0.238	<.001	<.001	3	28
STAD	Establishment of protein localization to vacuole →	+0.093	+0.282	<.001	<.001	3	28
STAD	Protein targeting to vacuole →	+0.055	+0.160	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,088 associations by consensus.

Autophagosome organization by MSH4 expression — STAD

Explore this box plot interactively →