MSH4

Across TCGA patient cohorts, MSH4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSH4-associated genes across cancer lineages are Notch1, Cyclin-B1, and Cyclin-E2. Each is linked with MSH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MSH4-to-partner and partner-to-MSH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MSH4-low versus MSH4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH4→partner) and Y-score (partner→MSH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.134	+1.778	.001	.007	3	3
UCEC	Cyclin-B1 →	+0.671	+1.807	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.100	+1.087	.047	.048	3	3
LUAD	4E-BP1_pS65 →	+0.197	+3.169	.006	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.158	-1.925	.001	.004	3	2
UCEC	Ku80 →	+0.151	+1.013	.032	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by MSH4 expression — UCEC

Explore this box plot interactively →