MSH4

Across TCGA cell cohorts, MSH4 RNA expression is significantly associated with the mutation status of many other genes, with 1,266 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSH4-associated genes across cancer lineages are CELSR3, ABCA3, and ITGB4. Each is linked with MSH4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MSH4-to-partner and partner-to-MSH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELSR3 grouped by MSH4-low versus MSH4-high in STOMACH.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH4→partner) and Y-score (partner→MSH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CELSR3 →	+3.070	+0.126	.008	.003	3	4
LARGE_INTESTINE	ABCA3 →	+3.321	+0.247	.002	<.001	3	4
BLOOD_Leukemia	ITGB4 →	+3.095	+0.117	<.001	<.001	3	4
LARGE_INTESTINE	MACF1 →	+1.744	+0.207	<.001	<.001	3	4
STOMACH	HDAC4 →	+3.321	+0.176	.003	<.001	3	3
LARGE_INTESTINE	GNAS →	+2.459	+0.170	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,266 associations by consensus.

CELSR3 by MSH4 expression — STOMACH

Explore this box plot interactively →