MSH2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MSH2 protein abundance is significantly associated with the RNA expression of many other genes, with 19,890 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MSH2-associated genes across cancer lineages are GINS1, FOXM1, and RFC5. Each is linked with MSH2 in more than 8 cancer types. Because this analysis shows association rather than direction, both MSH2-to-partner and partner-to-MSH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MSH2 versus GINS1 in LUAD, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH2→partner) and Y-score (partner→MSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADGINS1 →+1.142+0.388<.001<.00139
BRCAFOXM1 →+1.278+0.384<.001<.00139
LSCCRFC5 →+0.992+0.665<.001<.00139
UCECDKC1 →+0.854+0.320<.001<.00139
LUADCCNB1 →+1.293+0.354<.001<.00139
LSCCLRPPRC →+0.798+0.697<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 19,890 associations by consensus.

MSH2 vs GINS1 — LUAD

Per-sample scatter of MSH2 vs GINS1 in LUAD (Pearson r = 0.67).

Explore this scatter interactively →

Exploration