MSH2

Across TCGA cell cohorts, MSH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,964 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MSH2-associated GO terms across cancer lineages are DNA strand elongation, Regulation of chromosome condensation, and DNA-templated DNA replication. Each is linked with MSH2 in more than 19 cancer types. Because this analysis shows association rather than direction, both MSH2-to-partner and partner-to-MSH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by MSH2-low versus MSH2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH2→partner) and Y-score (partner→MSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation →	+0.224	+1.372	<.001	<.001	3	20
BLOOD_Myeloma	Regulation of chromosome condensation →	+0.220	+1.596	.002	<.001	3	19
BONE	DNA-templated DNA replication →	+0.160	+1.219	.002	<.001	3	19
LUNG_SCLC	Centrosome cycle →	+0.073	+0.864	.002	<.001	3	19
SOFT_TISSUE	G1/S transition of mitotic cell cycle →	+0.102	+1.177	<.001	<.001	3	19
BLOOD_Myeloma	Nuclear chromosome segregation →	+0.122	+1.368	.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,964 associations by consensus.

DNA strand elongation by MSH2 expression — BONE

Explore this box plot interactively →