MSH2

Across TCGA cell cohorts, MSH2 mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MSH2-associated genes across cancer lineages are PABPC1L2A, SPATA31A1, and ETDC. Each is linked with MSH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSH2-to-partner and partner-to-MSH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2A grouped by MSH2-low versus MSH2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSH2→partner) and Y-score (partner→MSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PABPC1L2A →	+0.024	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	SPATA31A1 →	+0.041	+4.191	.001	.007	3	1
BLOOD_Lymphoma	ETDC →	+0.877	+5.794	<.001	<.001	3	1
BREAST	KIR3DL1 →	+1.575	+4.781	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.052	+3.169	.007	.009	3	1
LARGE_INTESTINE	GABRE →	-1.785	-3.169	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

PABPC1L2A by MSH2 expression — BLOOD_Lymphoma

Explore this box plot interactively →