MSGN1

Across TCGA patient cohorts, MSGN1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSGN1-associated genes across cancer lineages are JNK2, Notch1, and GAPDH. Each is linked with MSGN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSGN1-to-partner and partner-to-MSGN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by MSGN1-low versus MSGN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSGN1→partner) and Y-score (partner→MSGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.322	+3.179	<.001	.010	3	2
UCEC	Notch1 →	+0.187	+2.183	.004	.033	3	2
UCEC	GAPDH →	+0.708	+2.321	.004	.034	3	1
UCEC	Ku80 →	+0.336	+2.598	.002	.006	3	1
UCEC	MEK1_p_S217_S221 →	-0.299	-2.999	.018	.035	3	1
UCEC	MEK1 →	+0.348	+2.999	.041	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

JNK2 by MSGN1 expression — UCEC

Explore this box plot interactively →