MSC

Across TCGA pan-cancer cohorts, MSC Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MSC data layer compared with 23 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher MSC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MSC expression acts as an unfavorable survival marker.

ESCA, LUAD, and LGG are the cancer types where MSC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.217	0.684	.001	30	view →
LUAD	OS	Median	All	0.339	0.701	.012	12	view →
LGG	DFS	Median	All	0.219	0.832	<.001	6	view →
BRCA	DFS	Median	All	0.294	0.903	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MSC–ESCA (OS)

Open the ESCA breakdown →