MS4A7

Across TCGA patient cohorts, MS4A7 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A7-associated genes across cancer lineages are EGFR_pY1068, Heregulin, and ACVRL1. Each is linked with MS4A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A7-to-partner and partner-to-MS4A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MS4A7-low versus MS4A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A7→partner) and Y-score (partner→MS4A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.302	-3.584	.005	.002	3	1
UCEC	Heregulin →	-0.141	-3.156	.009	.018	3	1
UCEC	ACVRL1 →	-0.150	-3.156	.011	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-2.794	.005	.003	3	1
UCEC	MEK1 →	+0.395	+2.115	.013	.019	3	1
UCEC	p21 →	+0.221	+2.807	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by MS4A7 expression — UCEC

Explore this box plot interactively →