MS4A7

Across TCGA cell cohorts, MS4A7 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MS4A7-associated genes across cancer lineages are NPVF, TAAR8, and OR4D5. Each is linked with MS4A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A7-to-partner and partner-to-MS4A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by MS4A7-low versus MS4A7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A7→partner) and Y-score (partner→MS4A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NPVF →	+0.011	+4.078	.002	.009	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

NPVF by MS4A7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →