MS4A5

Across TCGA patient cohorts, MS4A5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A5-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and FoxM1. Each is linked with MS4A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A5-to-partner and partner-to-MS4A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MS4A5-low versus MS4A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A5→partner) and Y-score (partner→MS4A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.100	-3.143	.023	.018	3	1
UCEC	EGFR_pY1068 →	-0.218	-2.321	.047	.034	3	1
UCEC	FoxM1 →	+0.226	+2.115	.046	.019	3	1
UCEC	GATA6 →	-0.191	-3.800	.006	<.001	3	1
UCEC	INPP4B →	-0.332	-2.102	.019	.019	3	1
UCEC	JNK2 →	+0.237	+3.196	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by MS4A5 expression — UCEC

Explore this box plot interactively →