MS4A5

Across TCGA cell cohorts, MS4A5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MS4A5-associated genes across cancer lineages are COX4I2, C1QC, and CXorf51A. Each is linked with MS4A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A5-to-partner and partner-to-MS4A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by MS4A5-low versus MS4A5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A5→partner) and Y-score (partner→MS4A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.098	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	C1QC →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.076	+4.887	<.001	.009	3	1
LARGE_INTESTINE	TAS2R60 →	+0.019	+3.347	.002	.005	3	1
LARGE_INTESTINE	SLN →	+0.158	+3.443	.003	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

COX4I2 by MS4A5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →