Across TCGA pan-cancer cohorts, MS4A4E Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MS4A4E data layer compared with 26 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher MS4A4E Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MS4A4E expression acts as an unfavorable survival marker.

OV, LGG, and LUSC are the cancer types where MS4A4E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.289	0.692	.020	18	view →
LGG	DFS	Median	All	0.249	0.738	.027	6	view →
LUSC	OS	Median	All	0.152	0.762	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MS4A4E tumor-vs-normal RNA expression · all MS4A4E data types