Across TCGA patient cohorts, MS4A4E mutation is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A4E-associated genes across cancer lineages are ATF4P2, C9orf43, and NEUROG2. Each is linked with MS4A4E in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4E-to-partner and partner-to-MS4A4E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4E→partner) and Y-score (partner→MS4A4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4P2 →	+0.050	+3.014	<.001	.004	3	1
UCEC	C9orf43 →	+0.520	+3.234	.001	.009	3	1
UCEC	NEUROG2 →	+1.133	+3.574	.002	.006	3	1
UCEC	NDUFAF5 →	+0.519	+3.245	.001	.009	3	1
UCEC	PRDM13 →	+0.369	+3.475	.006	.006	3	1
UCEC	ZIC5 →	+1.672	+3.600	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Exploration

MS4A4E survival (RNA) · tumor vs normal (RNA) · all MS4A4E data types