MS4A4E

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MS4A4E mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A4E-associated genes across cancer lineages are JNK_pT183_Y185, Src_pY416, and STAT3_pY705. Each is linked with MS4A4E in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4E-to-partner and partner-to-MS4A4E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4E→partner) and Y-score (partner→MS4A4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECJNK_pT183_Y185 →-0.225-2.986.021.03731
UCECSrc_pY416 →-0.296-2.986.034.03731
UCECSTAT3_pY705 →-0.442-3.000.003.03731
UCECCyclin-E2 →+0.226+3.009.020.01931
UCECNDRG1_pT346 →-0.677-3.000.016.03721
UCECPDCD4 →-0.583-3.000.032.03721
Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration