Across TCGA cell cohorts, MS4A4E mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MS4A4E-associated genes across cancer lineages are OR12D3, OR10G3, and SPATA31D1. Each is linked with MS4A4E in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4E-to-partner and partner-to-MS4A4E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4E→partner) and Y-score (partner→MS4A4E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR12D3 →	+0.006	+5.643	<.001	.002	3	1
LUNG_SCLC	OR10G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	SPATA31D1 →	+0.843	+5.643	<.001	.002	3	1
LUNG_SCLC	TEX50 →	+0.040	+5.643	<.001	.002	3	1
LUNG_SCLC	SERPINA2 →	+0.038	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8K3 →	+0.016	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

MS4A4E survival (RNA) · tumor vs normal (RNA) · all MS4A4E data types