MS4A3

Across TCGA pan-cancer cohorts, MS4A3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MS4A3 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher MS4A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MS4A3 expression acts as an unfavorable survival marker.

CESC, BLCA, and SKCM are the cancer types where MS4A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.068	0.756	<.001	18	view →
BLCA	OS	Median	IV	0.247	0.602	.040	6	view →
SKCM	OS	Median	All	0.333	0.780	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MS4A3–CESC (OS)

Open the CESC breakdown →