MS4A3

Across TCGA patient cohorts, MS4A3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A3-associated genes across cancer lineages are ACC_pS79, ACC1, and Mre11. Each is linked with MS4A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MS4A3-to-partner and partner-to-MS4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by MS4A3-low versus MS4A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A3→partner) and Y-score (partner→MS4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.364	+2.584	.024	.011	3	3
UCEC	ACC1 →	+0.393	+3.169	.020	.019	3	1
UCEC	Mre11 →	-0.087	-2.584	.029	.011	3	1
UCEC	TFRC →	+0.541	+3.000	.028	.036	3	1
UCEC	ATM →	-0.468	-2.986	.027	.035	3	1
UCEC	Chk1 →	-0.151	-3.140	.049	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ACC_pS79 by MS4A3 expression — UCEC

Explore this box plot interactively →