MS4A3

Across TCGA cell cohorts, MS4A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,983 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MS4A3-associated GO terms across cancer lineages are Disruption of plasma membrane integrity in another organism, Neutrophil-mediated killing of fungus, and Disruption of cellular anatomical structure in another organism. Each is linked with MS4A3 in more than 7 cancer types. Because this analysis shows association rather than direction, both MS4A3-to-partner and partner-to-MS4A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Disruption of plasma membrane integrity in another organism grouped by MS4A3-low versus MS4A3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A3→partner) and Y-score (partner→MS4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Disruption of plasma membrane integrity in another organism →	+0.669	+2.720	<.001	<.001	3	8
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+1.250	+2.639	<.001	<.001	3	8
BLOOD_Leukemia	Disruption of cellular anatomical structure in another organism →	+0.669	+2.720	<.001	<.001	3	8
BONE	tRNA transcription →	+0.111	+0.053	<.001	.003	3	5
SKIN	Cellular response to morphine →	+0.141	+0.098	<.001	.001	3	5
SKIN	Cellular response to isoquinoline alkaloid →	+0.141	+0.098	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,983 associations by consensus.

Disruption of plasma membrane integrity in another organism by MS4A3 expression — BLOOD_Leukemia

Explore this box plot interactively →